The Bears eased to victory by an innings and 202 runs to finish top of the table for the first time since 2004.
Having bowled out Division One's bottom club for just 60 on the opening day, Warwickshire declared at 471 for eight on Wednesday before Worcestershire reached stumps on 100 for two in their second innings.
The demolition job continued on Thursday with Warwickshire claiming the eight wickets required to wrap up the one-sided win shortly after lunch.
Only Moeen Ali's unbeaten 72 provided any resistance to Warwickshire's march towards the title, but when he ran out of partners his spirited defence was brought to an end.
Chris Wright finished as the pick of the Warwickshire attack in the second innings, finishing with figures of four for 65, including all three wickets after lunch.
Meanwhile, Yorkshire's final home game of the County Championship Division Two brought a first win at Headingley this season to strengthen their position in second place.
An emphatic eight-wicket win over Glamorgan was the Tykes' fourth of the season and was secured with a full day and 17.5 overs to spare
They now travel to Chelmsford for their final game of the season against Essex next week looking to wrap up promotion ahead of the club's 150th anniversary in 2013.
Elsewhere, Sam Northeast smashed a season-best 165 as Kent took charge against leaders Derbyshire at Canterbury. Brendan Nash added 62 Mike Powell 56 not out as Kent declared on 342 for eight.
Set 404 to win, Derbyshire were 30 for at stumps, skipper Wayne Madsen dismissed without scoring.
England spin bowler James Tredwell was at the centre of a dispute between Kent and Derbyshire ahead of their match at Canterbury.
The start of the third day of the contest between the two promotion chasers was clouded by Kent's decision to jettison rookie spinner Adam Riley and draft in their nominated replacement player Tredwell - just hours after his appearance in the final NatWest Series one-day international at Trent Bridge.
Derbyshire's head coach Karl Krikken described the manoeuvre as "moving the goalposts", and said: "They [the ECB] told us Tredwell could come in if he didn't play in that England game and we have an email to that effect. The rules were set at the start of the game, but it's like saying 'it doesn't matter, let's tear that up and he can play anyway'. It's wrong, it's totally and utterly wrong."
Liam Norwell claimed five wickets as Gloucestershire moved off the bottom of the table with a 207-run victory against Northamptonshire at Bristol. The 20-year-old seamer followed up his three for 23 in the first innings with five for 51 in a Northamptonshire second-innings total of 224 that featured half-centuries from David Sales and Andrew Hall.
Hampshire face an uphill battle to stave off defeat against Essex on the final day. Set a daunting 427 to win, Hampshire were struggling at 73 for three at stumps, requiring a further 354 runs to win.